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Tissue distributions at different time points are summarized in Figure 6

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Both overexpression of these proteins indicate exacerbation of autophagy inhibition

The utilisation of inhibitors of glutamine metabolism has been demonstrated to promote ROS formation and desensitization in PC cells, consequently resulting in altered cytokine-cytokine receptor interaction pathways, including those involving CCL5, CCR4, LTA, CXCR4, IL-6R and IL-7R, which in turn promote iron death [53]

In this review, we will focus mainly on DNA methylation inhibitors and discuss the different classes of DNMT inhibitors under development, relevant mechanisms involved, potential challenges and future directions