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doi: 10.1039/c3cc42394h 54 YuCBhaskaranRYangCC

Effects of external counter-pressure in the treatment of hemorrhagic shock

25,26 Right upper quadrant abdominal pain, in theory, results from stretching of the Glisson's capsule by hepatomegaly as a consequence of the increasing intrahepatic volume occupied by the developing hepatic granulomas

CAFs-induced ECM remodeling results in increased tissue stiffness and the activation of mechanotransduction signaling pathways, such as integrin-FAK and YAP/TAZ signaling, thereby conferring increased malignancy to tumors (121)