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In previous studies, the connection between effort-based motivated performance in humans and levels of various metabolites in the accumbal region, was measured using 1 H-MRS at 7 Tesla before performing a physical effort-based motivated task (MIFT) (16, 17)

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Inhalation methods, such as chasing the dragon, are associated with leukoencephalopathy, characterized by progressive motor and cognitive impairments, ataxia, and spastic paresis (Wolters et al., 1982), while diffusion tensor imaging highlighted impaired white matter connectivity due to myelin damage rather than axonal injury ( Heroin also induces psychiatric symptoms, such as depression, anxiety, impulsiveness, and interpersonal sensitivity (Tolomeo et al., 2021), are commonly observed