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These results suggest that the downregulation of GPx4 is critical for DOX-induced ferroptosis and that differential behaviors of GPx4 expression in response to DOX might be responsible for the susceptibility of DOX-induced injuries through ferroptosis

Honda, Y., Kessoku, T., Sumida, Y., Kobayashi, T., Kato, T., Ogawa, Y., Tomeno, W., Imajo, K., Fujita, K., Yoneda, M., Kataoka, K., Taguri, M., Yamanaka, T., Seko, Y., Tanaka, S., Saito, S., Ono, M., Oeda, S., Eguchi, Y

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Distinct distal visual cues were placed on the walls surrounding the tank

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