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Surgeon General report from 2010 also noted a single cigarette could cause immediate health problems and increase risk of heart attack

Differential responses to e-cig generated aerosols from humectants and different forms of nicotine in epithelial cells from nonsmokers and smokers

doi: 10.1007/s00038-015-0764-x 144

Here is a non-comprehensive list of intense drinking experiences I've been known to enjoy: Smith and Cross overproof Jamaican rum (my preferred sipping rum around the house until an acid reflux diagnosis put an end to that) Jeppson's Malrt A Trinidad Sour Grappa of dubious quality Moxie A Pink Gin made with the driest, Londoniest London Dry Gin available Shots of dill- and horseradish-flavored vodka, drunk in the Russian style with an assortment of smoked, salted, and pickled fish and vegetables Straight-up apple cider vinegar Literally every amaro I've had that wasn't Fernet Branca

doi:10.1016/j.jep.2006.05.034