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On the other hand, cysteine needs to be imported from plasma into the brain in order to synthetize glutathione (GSH), and this import is mediated by system X C (Figure 1)

While showing evidence of metabolic target engagement and tumor responses in select patients, toxicities including peripheral neuropathy and lactic acidosis have been dose-limiting

Taurine protects against many diseases linked to mitochondrial defects, such as aging, metabolic syndrome, cancer, cardiovascular diseases and neurological disorders, although it is not easily oxidized and cannot act directly as a free radical scavenger (Jong et al

But what happens when this system fails

This work reveals that metastasizing melanoma cells in lymphatic vessels experience less oxidative stress than cells in the blood because they are protected from ferroptosis, and thus are more efficient to form metastases