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[Abstract]2022 Mar 1;135(5):jcs259333

Sekiguchi N, Kameda H, Amano K, Takeuchi T: Efficacy and safety of bucillamine, a D-penicillamine analogue, in patients with active rheumatoid arthritis

Research peptides with animal studies Moderate evidence : Preclinical animal studies (mice, rats, larger animals) Mechanistic understanding Promising results Limited human data Examples : BPC-157: Extensive animal studies on healing Many healing peptides Some metabolic peptides Animal studies don't always translate to humans, but provide valuable insights

IL-1 antagonists have primarily shown efficacy in IMID which have associated familial genetic mutations in pathways involving IL-1

QDO is SD lacking tryptophan, leucine, adenine, and histidine, testing 2 reporters ( ADE2 and HIS3 )