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In summary, although selenium exhibits promise in mitigating the occurrence and progression of HCC, additional research is required to fully elucidate its effects, mechanisms, and to develop optimal strategies for its clinical implementation

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Figure 2 4.1 Mitochondria Multiple stresses can generate ROS in mitochondria by hindering and modifying the ETC and ATP generation, resulting in a surplus reduction in electron carriers and the generation of ROS ( 2 , which is catalyzed into H 2 O 2 by Mn-SOD and CuZn-SOD

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Funding This work was supported by research fund of Chungnam National University