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7 Of course, most of these patients will have no hematologic or neurologic manifestations of B 12 deficiency (ie, subclinical deficiency)

Results Summary: While early Phase 2 trials showed promising functional improvements (EX: increased distance walked in the 6 minute walk test in PMM patients), large Phase 3 trials have been complex and have sometimes failed to meet primary endpoints, underscoring the challenge of treating complex mitochondrial disorders

Indeed, it is known that hydrochlorothiazide can target several ion transporters and enzymes including SLC4A8 , a Na + -dependent Cl /HCO 3 exchanger (NDCBE), SLC26A4 , a Na + -independent Cl /HCO 3 exchanger (Pendrin) and carbonic anhydrases (Pickkers et al., 1999

Role of thyroid hormone during early brain development