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Mitochondrial antioxidant proteins in the first line of defense against ROS/RNS fall into three categories, including non-enzymatic antioxidants (i.e., GSH), direct enzymatic antioxidants (i.e., SOD2 and GPx), and indirect enzymatic antioxidants [i.e., glutathione reductases (GR), peroxiredoxins, and thioredoxins (Trx)] [96, 97]

The plate was incubated for 24 h, and fluorescence intensity was determined as above

For instance, administering statins alongside OATP1B1 inhibitors like gemfibrozil (a lipid-lowering agent) or cyclosporine A (an immunosuppressant) can elevate statin serum levels, thereby increasing the risk of statin-induced myopathy [27]

Adv Enzyme Res (2013) 2013

Glutathione peroxidases (GPx, EC 1.11.1.9) Glutathione Peroxidase (GPx) is an important intracellular enzyme that breakdown hydrogen peroxides (H2O2) to water