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To evaluate whether mutants deficient in different glutathione-dependent enzymes are impacted by TMHT, we subjected cytosolic glutaredoxin mutants to TMHT (Figure 4C)

4-hydroxynonenal induces apoptosis via caspase-3 activation and cytochrome c release

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The transit of orally administered GSH to tissues is thought to occur via absorption from the intestinal lumen, export from enterocytes into the blood, and uptake from the plasma into cells

Even though the main function of the kidney is to excrete waste products from the bloodstream, it is important to mention that the kidney is also a major endocrine organ