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This three year trial tested a PRAL diet vs bicarbonate supplementation in CKD patients and showed that the PRAL diet was more effective in preserving GFR and decreasing excretion of beneficial hormones (Goraya et al., 2014)

The same potent growth-promoting effects that make it attractive also create real risks that demand respect

To make this point clear, a method like IDOL would be advantageous only if the original marker selection contains a significant number of false positives driven by such confounders, yet as shown here, IDOL would also require a larger training set for this advantage to become apparent

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10.1111/j.1365-2303.2009.00677.x Cytopathology 17 BatenburgJ