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These insights have led to therapeutic strategies targeting hypoxia and tumor metabolism, including HIF-2 inhibitors (e.g., belzutifan), hypoxia-activated prodrugs, anti-angiogenic agents, glycolysis and glutaminase inhibitors, lactate transport blockers, CAIX inhibitors, and immunometabolic modulators aimed at reversing hypoxia-induced immune suppression [ Table 1 ]

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Crit Rev Food Sci Nutr 63(26):84038427 Rahimi P, Mesbah-Namin SA, Ostadrahimi A, Abedimanesh S, Separham A, Jafarabadi MA (2019) Effects of betalains on atherogenic risk factors in patients with atherosclerotic cardiovascular disease

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This medication is a diet supplement used to prevent and treat low blood levels of carnitine