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Material and method In vivo model Our experimental procedure has been reported in accordance of the ARRIVE2.0 guidelines

See also: ASH Key Topic Heated tobacco 5.3 Shisha About one in twenty adults report using shisha at least yearly (2.2%), including 0.8% who use it at least monthly

Nicotine dependence also plays into this

They do not replace cheap cigarette alternatives but can significantly help smokers suffering from significant nicotine dependency