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Galectin-3 has an AUC of 0.83 with 72.1% sensitivity and 86.1% specificity, while S100A9 has an AUC of 0.77 with 69.8% sensitivity and 58.1% specificity (Table.1)( Figure 4C ) (103)

Within the realm of bone tissue engineering, this microenvironment comprises both osteogenic and immune cell lineages, including mesenchymal stem cells (MSCs) and pre-osteoblasts as the principal osteogenic cells, and macrophages as the dominant immune cells ( The complexity of the bone defect microenvironment makes cells vulnerable to various factors during regeneration and repair, creating substantial challenges for bone healing and clinical implementation of bone tissue engineering

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Although Sesn2 was manipulated genetically rather than pharmacologically in that study, both Sesn2 itself and its upstream regulators, mTOR and AMPK, are in principle amenable to small-molecule targeting

The body downregulates metabolic rate, adjusts hunger hormones, and becomes more efficient at storing energy