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For instance, while quercetin has been reported to activate both enzymes, curcumin has shown potential as an activator of SIRT1, promoting its deacetylase activity and contributing to anti-inflammatory effects 178

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doi: 10.1136/bcr-2012-006271 53 Ros-PrezPGolmayoLCillerueloMLGutirrezCCelayaPLacmaraNet al

GHK-Cu is commonly studied as a copper-binding peptide complex in laboratory models investigating cellular signaling, oxidative balance, and extracellular matrixassociated pathways