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Oxidized LDLs play crucial roles in initiating and amplifying inflammatory responses at lesion sites, promoting leukocyte recruitment, and contributing to atherosclerosis progression through vascular smooth muscle cell activation and reduced nitric oxide bioavailability

Although many dermatomyositis patients can be effectively treated with current options, either as monotherapy or with combination regimens, there is a need for more targeted and effective DM therapies, in general, and for MDA5(+) dermatomyositis-associated rapidly progressive interstitial lung disease

Plant J 49:878888 Ohkama-Ohtsu N, Oikawa A, Zhao P, Xiang C, Saito K, Oliver DJ (2008) A -glutamyl transpeptidase-independent pathway of glutathione catabolism to glutamate via 5-oxoproline in Arabidopsis