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Yes, it is perfectly normal

Topical effects Most reported topical effects are mild and local: redness, tingling, dryness, or transient irritation at the application site, typically more common with concentrations above 4%

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23 The NAD + level can be elevated by dietary supplementation of NAD + precursors, such as Trp, NA, NMN and NR, inhibition of NAD + -consuming enzymes, including PARP1 and CD38, management of the NAD + biosynthesis via controlling NAD + -biosynthesis enzymes, or improving NAD + bioavailability through exercise and caloric restriction

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