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Gizurarson, S

Taken together, evidence from human trials indicates that polyphenol supplementation can meaningfully modulate acute exercise-induced oxidative stress and selected inflammatory pathways, even when effects on performance or soreness are inconsistent or secondary

For most healthy adults, 2,000 mg is considered the maximum safe oral dose, but taking this much long-term is generally unnecessary and can lead to digestive upset

When a study engages in questionable research practices (QRPs) and ignores these previously detailed, scientifically determined hazards of the premature administration of pimobendan (over-stimulating the well-compensated heart's contractility), and instead the study is based upon superficial appearances (a heart's linear dimensions exceeding arbitrary minimums), that study can easily lead to false positives

doi: 10.1111/jpi.12682 214 FathizadehHMirzaeiHAsemiZ