Schiffrin EL, Park JB, Intengan HD, Touyz RM
Glossary PD Parkinsons disease DA dopamine CNS central nervous system DA neurons dopaminergic neurons TH tyrosine hydroxylase AADC aromatic acid decarboxylase NG2 neuron/glial 2 SN Substantia nigra VMAT2 Vascular Monoamine Transporter 2 DA dopamine transporter FAD flavin adenine dinucleotide MAO monoamine oxidase HD Huntingtons disease ROS oxygen species MPTP 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine LPS lipopolysaccharide -syn -synuclein LRRK2 Leucine-rich repeat kinase 2 GBA Glucocerebrosidase PRKN Parkin RBR E3 Ubiquitin Protein Ligase PINK1 Parkin RBR E3 Ubiquitin Protein Ligase DJ-1 Parkinson Disease Protein 7 IL-1 Interleukin-1 IL-2 Interleukin-2 IL-6 Interleukin-6 IL-10 Interleukin-10 TNF- Tumor Necrosis Factor- CSF cerebrospinal fluid BBB blood-brain barrier NLRP3 NOD-, LRR- and pyrin domain-containing protein 3 P2X7 P2X purinoceptor 7 NOx NADPH oxidase NOS1 Nitric Oxide Synthase 1 NOS3 Nitric Oxide Synthase 3 H1R Histamine H1 Receptor H4R Histamine H4 Receptor PKC protein kinase C delta NLRP3 Nucleotide-binding oligomerization domain, Leucine rich Repeat and Pyrin domain-containing Protein 3 GSH Glutathione MT metallothionein Nrf2 Nuclear factor erythroid 2-related factor 2 SOD superoxide dismutase GPX glutathione peroxidase NO nitric oxide CBS Cystathionine - Synthase PAR-1 Protease-activated receptor-1 ERK Extracellular signal-regulated protein kinase CD44 Cluster of Differentiation 44 P2Y2 Purinergic Receptor P2Y2 GCI glial cytoplasmic inclusions CP Ceruloplasmin TF Transferrin TFR Transferrin Receptor FPN Ferroportin DMT1 Divalent Metal Transporter 1 FTL ferritin light chain Ols oligodendrocytes TRPML1 transient receptor potential mucolipin 1 HO-1 Heme oxygenase-1 DFP desferridone PQT Paraquat LXR Liver X Receptor WNT Wingless/Integrated PPAR- Peroxisome Proliferator-Activated Receptor- PEA palmitoylethanolamide NF- B Nuclear Factor-kappa B O2- Superoxide anion OH hydroxyl radicals References 1 AbbaszadehH
liposomal delivery protects the molecule so it can be absorbed at the cellular level where it is needed
6-TG, which had been synthesised before 6-MP, was more difficult to manufacture and more toxic, leading to 6-MP being favoured
10.1111/apha.13623 75 HanW.ShepardR
