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These same strains have also exhibited anti-angiogenic potential by downregulating COX-2 expression, an enzyme linked to tumorigenesis, blood vessel growth (angiogenesis), and cancer cell survival (234)

Iwase T, Oveson BC, Hashida N, Lima e Silva R, Shen J, Krauss AH, Gale DC, Adamson P, Campochiaro PA

coli expression that differ substantially from the methods described for baculovirus expression

The C-terminal sequences are slightly different between dithiol and monothiol Grxs [32] and it seems to affect GSH binding and may explain the biochemical differences between the two mechanisms of action

Kopetz S , Grothey A, Ciardiello F, Desai J, Kim TW, Maughan T, Cutsem EV, Wasan HS, Yaeger R, Yoshino T, Gollerkeri A, Edwards M, Lizaso MR, Tabernero J