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To examine the effect of NO and ONOO on cathepsin peptidase activity, the cathepsins were preincubated with NOR-3 (10, 1 and 0.1 M

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Disclosures: Haruhiko Takeda: Nothing to Disclose, Atsushi Takai: Nothing to Disclose, Masayuki Ueno: Nothing to Disclose, Yosuke Fujii: Nothing to Disclose, Masako Mishima: Nothing to Disclose, Tadashi Inuzuka: Nothing to Disclose, Hiroshi Seno: Nothing to Disclose 1909 HIGH PROXIMITY OF TREG-CD8T/CD4T CELL INTERACTIONS IN SPATIAL OMICS ANALYSIS REGULATING CANCER PROGRESSION IN PATIENTS WITH HEPATOCELLULAR CARCINOMA Junki Yamashita 1 Takuto Nosaka 1 Yosuke Murata 1 Tomoko Tanaka 1 Yu Akazawa 1 Tatsushi Naito 1 Kazuto Takahashi 1 Masahiro Ohtani 1 Yasunari Nakamoto 1 , 1 Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui Background: The tumor immune microenvironment influences clinical outcome, but the spatial relationships between immune cells in hepatocellular carcinoma (HCC) are not well elucidated

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