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Clin Microbiol Rev 26(4):744758

4.5 KRAS mutation in pancreatic cancer diagnosis and prognosis As one of the most devastating digestive system cancers, PDAC is characterized by a lack of specific symptoms, fast progression, and poor prognosis ( KRAS mutation and cytopathology increased the sensitivity, accuracy, and negative predictive value of pancreatic cancer diagnosis and molecular subtype classification

These cellular events might translate into clinical responses like prevention or attenuation of disease states or adverse effects (Figure 1)