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50 Increased neuronal iron disrupts neuromelanin-iron complexes, releasing toxic free iron and causing neuromelanin leakage, which further drives microglial M1 polarization and neurotoxin release

Ascorbic acid and glutathione in this cycle can maintain protein stability and cell membrane integrity, and together with APX and GR, constitute the ascorbate-glutathione cycle (Miao et al., 2021)

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