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Figure 3 illustrates the regulatory mechanism of the Keap1-Nrf2 signaling pathway

Bouligny I, Montalban-Bravo G, Sasaki K, Daver N, Jabbour E, Alvarado Y, DiNardo C, Ravandi F, Borthakur G, Bose P, Pemmaraju N, Kornblau S, Kadia T, Masarova L, Takahashi K, Andreeff M , Kanagal-Shamanna R, Hosing C, Pierce S, Meyer M, Huang X, Kantarjian H, Garcia-Manero G

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These findings indicate that AGH treatment effectively attenuates ROS, mitochondrial oxidative stress and enhances mitochondrial antioxidant defenses in mdx mice

AS catalyzes the formation of argininosuccinate from citrulline and aspartate and is degraded in the liver during liver injury and released into the circulation