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However, in a smokers lungs, nicotine paralyzes and destroys these cilia, preventing the removal of harmful particles and allowing mucus buildup that leads to conditions like chronic bronchitis, pneumonia, and emphysema

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Table 3: Common Treatment Emergent AEs (%) in the Fixed-Dose, Placebo- Controlled Studies (HLGTs 5% of patients in the 1 mg BID CHANTIX Group and more commonly than Placebo and PT 1% in the 1 mg BID CHANTIX Group, and 1 mg BID CHANTIX at least 0.5% more than Placebo) The overall pattern and frequency of adverse events during the longer-term premarketing trials was similar to those described in Table 3, though several of the most common events were reported by a greater proportion of patients with long-term use (e.g., nausea was reported in 40% of patients treated with CHANTIX 1 mg twice daily in a one year study, compared to 8% of placebo-treated patients)

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