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Tars K, Larsson A-K, Shokeer A, Olin B, Mannervik B, Kleywegt GJ

The amount of copper delivered topically is far too small to cause skin discoloration

Collectively, these results suggested that APR-017 and LCS3 treatment induce vulnerability of VRK2-deficient PC cells by GSH inhibition and consequent disruption of the balance between ROS generation and antioxidation

J.YuX.CordesB.-I

In the SK-N-BE cells, DOR desensitization is reduced when arrestin 2 expression is inhibited by shRNA only upon DPDPE and deltorphin I exposure but not with etorphine (Aguila et al., All those data indicate that different mechanisms are responsible for OR desensitization: some are arrestin-dependent and requires GRK while others are arrestin-independent