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[94] [95] Cancer [edit source] Contrary to popular belief, nicotine itself does not cause cancer in humans, [97] [98] although it is unclear whether it functions as a tumor promoter as of 2012 [99] A 2018 report by the US National Academies of Sciences, Engineering, and Medicine concludes, "[w]hile it is biologically plausible that nicotine can act as a tumor promoter, the existing body of evidence indicates this is unlikely to translate into increased risk of human cancer." [100] Although nicotine is classified as a non-carcinogenic substance, it can still theoretically promote tumor growth and metastasis as evidenced from alterations

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