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Supplementary Table S3-4 )

Noteworthy, Th17 cells play a critical role not only in host defense but also in tissue regeneration, including skin and mucosa (118), whereas Treg cells are deputed to the negative control of immune responses and are required for the maintenance of immune tolerance (119)

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With the advancement of research in this field, targeting a specific process allows avoidance of global changes influenced by previous strategies such as glucocorticoids and can neatly reverse a phenotype by re-establishing a balance between fission and fusion

demonstrated a mitochondrial DNA depletion syndrome-2 patient caused by TK2 compound heterozygous mutation