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In the course of the dismutation reaction, the Mn ion is cycling from a more stable Mn(III) oxidation state to a less stable Mn(II)

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Prolonged exposure to excessive ROS leads to mitochondrial dysfunction, endoplasmic reticulum stress (ER stress), the unfolded protein response (UPR), impaired proteasome function, and dysregulation of autophagy regulated by peroxisomes, causing a series of uncontrolled reactions [19]