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Compared to healthy controls, MS patients show significantly downregulated expression of TET2 in peripheral blood mononuclear cells (PBMCs), correlating with abnormal methylation patterns in the promoter regions of TET2 and DNMT1 (134)

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109,464 Both GFAP-positive astrocytic profiles and 3D reconstructions of astrocytes expressing green florescent protein in the nucleus accumbens of rats addicted to cocaine show atrophic morphology, with the volume of reconstructed cells decreasing by 19% and surface area by 21% as well as reduced synaptic coverage