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Endogenous examples include glutathione (-glutamyl-cysteinyl-glycine) and thioredoxin, both of which can effectively scavenge ROS such as hydroxyl radicals (OH), hydrogen peroxide, and peroxynitrite (ONOO - ) without enzymatic assistance

11,38 Caffeine is a methylxanthine, a group of non-selective antagonists of adenosine receptors that includes aminophylline, theophylline and caffeine

Direct Absorption : Coffee is absorbed through the rectal veins and transported directly to the liver via the portal vein, where it may influence liver function and potentially boost glutathione synthesis

Abstract Myalgic encephalitis/chronic fatigue syndrome (ME/CFS) is a common debilitating medical condition, whose main symptoms - fatigue, post-exertional malaise and cognitive dysfunction are also present in many cases of long COVID

In research, it is studied for tissue repair, gastrointestinal barrier function, and angiogenic mechanisms