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As with any peptide, there could be risks, such as injection site reactions, water retention, or possible changes in insulin sensitivity

For researchers, this means: Published Phase 3 trial data available for reference Well-characterized safety profile from prescription use Ongoing clinical trials for additional indications (NAFLD, cognitive function) Clear differentiation from research-only peptides like BPC-157 or TB-500 For comprehensive information on FDA-approved peptides across all therapeutic categories, see our FDA Approved Peptides List 2026 guide

From a dieting standpoint, it can also help reduce the craving for food

Some people with vitamin B12 deficiency may experience depression or mood changes, and vitamin B12 injections may help to improve mood in these cases

Peter Attia MD